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Notably, AcM concentration also led to a decreased ability of the caecal microbiota to generate energy through functions such as glycolysis and to a reduction in the metabolism of ribosomal protein and nucleotides, together with a depletion of DNA homologous recombination, replication, and mismatch repair

Indeed, the specific activity of Cu/Zn-SOD was elevated by 60% in liver biopsies obtained from MASLD patients than in control livers

All constructs and gene sequences used in this study were either commercially synthesised, generated by standard molecular cloning approaches or were generated in previous studies (Supplementary Information

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