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Single-cell RNA sequencing (scRNA-seq) of ECs from LDLR / mice fed a diabetogenic HFD identified three EC clusters expressing mesenchymal markers, showing reduced fatty acid oxidation, increased inflammation, and altered extracellular matrix organization [92]

Overall, NAC can facilitate alveolar bone regeneration by promoting bone formation and inhibiting bone resorption, thus enabling a positive therapeutic effect for periodontal tissue defects caused by periodontitis

The integrative analysis of transcriptome data allowed us to delineate the metabolic behaviour and regulation relevant to the higher growth rate observed in sucrose as compared to glucose: (i) upregulation of the genes in sucrose assimilation, (ii) net upregulation of genes for biomass precursor biosynthesis, and (iii) downregulation of PGI, ACALD and RPE which are negative flux control points of mannitol production (Fig