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[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered

Lipopolysaccharides (LPSs) from the outer membrane of Gram-negative bacteria may translocate through the intestinal border and cause subsequent systemic inflammation (247)

Integrated Network of Mitochondrial Homeostasis in the Heart The preceding sections have detailed the distinct regulatory layers regulating mitochondrial biology, including transcriptional control of biogenesis, epigenetic fine-tuning, dynamic fission and fusion, and quality-controlled mitophagy

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