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Results obtained in rats castrated before puberty (3 weeks of age) were taken as supporting this hypothesis, since the penile AR concentration remained at immature levels at 7 and 13 weeks after castration, but decreased to the respective age levels if DHT was administered immediately after castration.2 However, it should be noted that the total penile AR content in the castrated animal reaching adulthood remained as low as in the adult animal because the penis grew very little in that period

Importantly, these metabolic changes can occur in women of all body sizes, highlighting that PCOS is not simply a weight-related condition

However, patients from the RIPENAC group did present with higher plasma levels of IL-1 (p = 0.034) and of IP10/CXCL10 (p = 0.025) than those from the RIPE group ( Table S1 )