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Consequently, AML is associated with a decrease in the expression of TJ proteins (claudin-1 and ZO-1) with a resultant increase in the translocation of LPS into the systemic circulation to promote inflammatory responses that favor the progression of the disease [110]

For researchers, these findings highlight Epithalon as an intriguing tool for exploring pineal-pineal axis regulation, chronobiology, and age-associated endocrine decline