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Hence, targeting both of them simultaneously might be a promising approach to hinder therapeutic resistance by blocking all potential alternative routes

Bremelanotide provides a treatment alternative for individuals who cant tolerate other treatments well or for men who do not respond to other treatments, such as sildenafil and tadalafil, which can lose their effectiveness over time

Dobie et al

The high reactive oxygen consumption by the brain enhances the brains susceptibility to oxidative stress to which endothelial cells are more sensitive compared to pericytes, and pericytes are more sensitive than astrocytes [82]