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Although iron chelators can inhibit ferroptosis by reducing the labile iron pool, their long-term use is associated with adverse effects such as ototoxicity, neurotoxicity, and allergic reactions ( in vivo , low bioavailability, and potential off-target effects ( In contrast, TCM, characterized by its multi-component, multi-target actions and low toxicity, along with its personalized strategies based on syndrome differentiation and a favorable safety profile, can simultaneously regulate gut microbiota composition, promote the production of beneficial metabolites, inhibit inflammatory pathways, and modulate key ferroptosis molecules

Australas J Dermatol 62:130140

These NPs are designed to deliver antioxidants more effectively to target sites, enhancing their therapeutic potential

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