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The responder rates were 82% for propranolol and 94% for topiramate ( P = 0.001) (Table)

For the quantification of Kim-1 and Ngal stainings (staining score), 5 and 10 images (2 at each magnification, for a total of 4 per mouse) were likewise graded with 0 (no staining), 1 (mild), 2 (moderate), or 3 (intense) based on intensity and area of the staining

10.1016/0026-0495(92)90061-E Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T: Valproic acid overdose and L-carnitine therapy

Sleep deprivation, mood disorders, chronic stress, and early adverse life events can lead to allostatic regulation alteration through neural plasticity