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However, due to their distinct underlying mechanisms, each extraction method presents unique advantages and limitations (Table 2)

3: Folate Metabolism For the reasons listed, vitamin-based drug delivery systems offer significant benefits over other drug delivery methods, such as monoclonal antibodies: The effective delivery of the conjugate into the tumor is possible only due to the Folates relatively lower size, (molecular weight is 441) whereas typical monoclonal molecular weights exceeding 150,000 makes it simpler to reach cancer cells

however, the limitations of the studies conducted to date, including a reliance on animal models, a lack of standardization across studies with regard to reporting methods, and the use of non-powered proof-of-concept studies, all impair the overall strength of the evidence currently available for the use of engineered bacteria in clinical settings (11, 28, 64).Animal Disease Models are Commonly Used

doi: 10.1074/mcp.M900430-MCP200 74 LeveugleB.DingW.LaurenceF.DehouckM