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Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

doi: 10.3389/FPHAR.2023.1147414 263 Amir AslaniBGhobadiS

Biolo G, Toigo G, Ciocchi B, Situlin R, Iscra F, Gullo A, Guarnieri G: Metabolic response to injury and sepsis: changes in protein metabolism