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When two such S-shape fibrils pack into 2-layer models, the inter-chain interactions on the packing surface enhance further the stability of fibrils and decrease its flexibility reducing the twist even more

In addition, they have been adapted as tools for gene location detection [106], epigenetic research [107], and even modified RNA targeting (Figure 1) [108]

The authors found that the phenotypic correction persisted in the iPSCs and their derived neurons, with GAA-corrected neurons expressing roughly threefold frataxin in comparison to control non-GAA-edited neurons derived from non-GAA-edited iPSCs [80]