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Abbreviations 2M: Beta-2-microglobulin CAPP: Concerted Action Polyp Prevention CEA: Carcinoembryonic antigen CI: Confidence interval CRC: Colorectal cancer CTLA-4: Cytotoxic T-lymphocyte antigen 4 dMMR: Mismatch repair deficient EMT: Epithelialmesenchymal transition FDA: US Food and Drug Administration FSP: Frameshift peptide HDAC: Histone deacetylase HNPCC: Hereditary non-polyposis colon cancer HPV: Human papillomavirus ICI: Immune checkpoint inhibitor KIR2DL1: Killer cell immunoglobulin-like receptor 2DL1 LS: Lynch syndrome LS-CRCs: Lynch syndromeassociated colorectal cancers MAb: Monoclonal antibody MLH1: mutL homolog 1 MSH2: mutS homolog 2 MSH6: mutS homolog 6 MMR: Mismatch repair MSI: Microsatellite instability MSS: Microsatellite stability MUC1: Mucin 1 NK: Natural killer NSAID: Nonsteroidal anti-inflammatory drug OS: Overall survival PD-L1: Programmed death-ligand 1 PFS: Progression-free survival PMS2: Post-meiotic segregation increased 2 TIL: Tumor-infiltrating lymphocyte TME: Tumor microenvironment Treg: Regulatory T cell References Papers of particular interest, published recently, have been highlighted as: Of major importance Le DT, Kim TW, Van Cutsem E, Geva R, Jager D, Hara H, et al

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