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NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues

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The magenta color represents the similar elements between the two molecules, including atoms as well as bonds, while the rest of the representation is the non-similar elements

Alisi A, Pampanini V, De Stefanis C, Panera N, Deodati A, Nobili V, Cianfarani S