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Increased levels of oxidative and nitrative metabolites promote lipid peroxidation, protein modification and genotoxic lesions

The identification of the relationship between GPxs and breast cancer is valuable for the discovery of potential therapeutic targets for breast cancer

These include: Oxidative stress: One of the more recent studies on DSIP, from 2011, concluded that the peptide has a strong antioxidant effect owing to an ability to activate the (rat) bodys natural mechanisms against oxidative stress.21 Edema (swelling via fluid buildup): Again in rats, a 1992 study suggested that DSIP may have an antiedematic effect related to the activation of the GABAergic system and inhibition of serotonin, noradrenaline, and histamine systems.22 Convulsions: Two rodent studies in the 1990s support DSIPs use as an anticonvulsant

Carmustine is an alkylating agent and is known under the brand name BiCNU (Ewend et al