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1.3 Operationalizing the meat processing exposome For the purposes of this chapter, we define the meat processing exposome as the totality of chemical exposures arising directly from or mediated by the thermal processing of animal-source foods, encompassing three hierarchically organized domains ( Figure 1 )

Figure 2 3.2 TNF triggers the release of mtDNA and the activation of cGAS-STING signaling in RA TNF, a multifunctional cytokine for homeostasis and disease pathogenesis, is highly expressed in rheumatoid joint tissues (55)