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Recovering the ability of the disc to repair the ECM, re-establishing the proteoglycan content, may have a significant therapeutic effect by increasing disc hydration and thereby improving its biomechanics (Vadal et al., 2015)

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Similarly, untreated slices displayed a reduction in GFAP expression at 1 week ( p = 0.00007), 3 weeks ( p = 0.0006) and 5 weeks ( p = 0.0000003) from that at 72 h

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