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A growing body of literature has highlighted the capacity of BDG to induce long-term epigenetic reprogramming in innate immune cells, termed trained immunity, which leads to an adjusted response to a subsequent challenge and to some metabolic changes, including a switch from oxidative phosphorylation to aerobic glycolysis (10, 11)

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While NAD+ focuses on mitochondrial energy production and DNA repair, peptides are generally used for targeted signaling and tissue regeneration