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Studies on MTHFR variants show no interactions with vaccinations, with the exception of a smallpox vaccine that is not regularly given

that nearly no other countries have approved use of these products

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Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects