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This family bifurcates into anti-apoptotic and pro-apoptotic groups, exemplified by Bcl-2 and Bax, respectively [68]

In a trial that enrolled 20 pet dogs with idiopathic inflammatory bowel disease, administration of a commercially available probiotic (VSL#3) in amounts providing 112.5125 billion colony forming units (CFUs) per 10 kg body weight per day for 60 days led to a significant decrease in clinical and histological scores

These data imply that, while metabolic regulation remains a promising target, it may not be sufficient as a standalone treatment after advanced neurodegeneration has occurred (176)