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In light of the fact that HOCl is a highly effective thiol oxidant (it is, after all, the main factor in the oxidation of thiols in phagocytized bacteria [179] and leads to a full collapse of the bacterial thiol redox homeostasis [335]), we concluded that neutrophils must have a highly effective defense that prevents HOCl or other reactive chlorine species from leaving the confines of the phagolysosome, at least in amounts that could affect the overall thiol redox state of the neutrophils cytosol

doi: 10.1126/science.281.5376.565 98 NishikawaHSatoEBrionesGChenLMMatsuoMNagataYet al

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