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and the receptors (AhR, ER, PPAR and TNFR2) [62,63,64]

For the synthesis of new chlorin PSs chlorophyll a is isolated from natural plants or algae, and converted to methyl pheophorbide a (MPa) as an important starting material for further synthesis

For instance, one trial reported worsening motor symptoms in patients with early-stage PD, highlighting the complexity of iron-targeted therapy (52,60,124)

Ultimately, these questions will be answered in upcoming phase 2 studies, including an ongoing phase 2a study of TLC-2716 in individuals with overweight/obesity with moderate-to-severe hypertriglyceridemia (TG 350 mg dl 1 ) and MASLD (NCT06564584)