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Behav Brain Res 393:112773

In: Postharvest physiology and Biochemistry of Fruits and Vegetables, pp

Genome-wide analyses reveal thousands of differentially methylated sites affecting steroid hormone signaling and inflammation pathways ( Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis

Indeed, a recent systematic review and narrative synthesis concluded that lower skin conductance level in individuals with depression versus healthy controls has been a consistent finding 37