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78 Pharmacological inhibition of HSP90 improves insulin sensitivity and reduces inflammation in experimental models, suggesting that selective targeting of HSP90 may be beneficial in certain metabolic contexts

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In EAE, disease severity as well as oligodendrocyte and neuronal death were ameliorated through treatment with antagonists to the AMPA/Kainate or NMDA type of glutamate receptors ( A recent study in a chronic progressive model of EAE has shown that astrocytes produce and are stimulated by the sphingolipid lactosylceramide (LacCer) (92)