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Laboratory studies in photoaging models show that combined peptide approaches addressing multiple regenerative pathways produce superior outcomes compared to single-agent interventions, with improvements in collagen organization, elastin fiber quality, hyaluronic acid content, and overall dermal architecture

It applies to clinical trials that use different extraction forms, for example, curcumin-containing substances with unspecified amounts of curcuminoids that prevent establishing the equivalency of doses or the minimum therapeutic threshold Large, more centralized, and strictly controlled clinical trials are required in the future to provide more scientific evidence to assess conferred benefit and a more secure way for adding these natural supplements to evidence-based treatment options for breast cancer

A randomised controlled trial is considered the gold standard of clinical evidence

2014 Feb;13(1):8-12