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The increase in the activity or quantity of EnaC induces an increase in sodium reabsorption by epithelial cells, which plays a role in the development of Liddle syndrome

To ensure these effects were not cell-line specific, we investigated the impact of J8 and J10 in two other lung cancer cell lines with elevated DDX3X expression, NCI-H460 and NCI-H1975, obtaining similar results (Fig

The role of ROS as a pathological player has been reported in various other cancers including astrocytic and ependymal glial tumors 68 , colorectal cancer 69 , kidney tumor 70 and breast cancers 71

These treatments do not eliminate pigment but regulate its formation