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However, supplementation with sodium selenite (1000 g per 2 h) increased MDA levels significantly by the fifth day of treatment, [31] which may be related to pro-oxidant effects of Se at high doses

Signal Transduction Targeted Ther 2022;7:48

Cell Calcium (2011) 50:48190

In the future, preoperative GPx3 measurement as well as the identification of specific risk constellations, including factors such as advanced age and the knowledge of the above defined subgroups, may help to improve the precision and success of adjuvant high-dose selenium treatment