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Upregulation of ATP7A or exposure to the copper chelator tetrathiomolybdate (TTM) results in reduced phosphorylation of ERK1/2, indicating that copper bioavailability represents a KRAS-selective vulnerability

However, more studies are required to further clarify and demonstrate this effect conclusively [48]

Forman HJ

Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers