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The endothelial cells are tightly connected by intracellular junctions that play a crucial role in maintaining the highly selective permeability of the BBB, allowing it to regulate the movement of ions, molecules, and cells between the blood and the neural tissue (84, 85)

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Doseinjury relationship: When NAPQI production exceeds glutathione supplythrough high single doses, high cumulative daily doses, or impaired conjugation/low GSHcentrilobular hepatic necrosis can occur