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Hyperchromic macrocytic megaloblastic anemia (pernicious anemia, Biermer's anemia, Addison's anemia these are disorders of maturation of the blood cells)

TAF, a novel prodrug of tenofovir, is a first-line recommended treatment for CHB and has shown efficacy comparable to TDF with higher rates of ALT normalization and no resistance

This approach appeared to slightly improve solubility, although there was variability across experiments due to the nature of the technique so further investigation would be required to confirm this