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Altogether, our work revealed a paradigm for the autoregulatory control of metabolic homeostasis in organelles

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The dual enzyme activities of FeS 2 reduce intracellular GSH levels and generate huge OH to disrupt redox homeostasis and mitochondria integrity, thus significantly reducing radiotherapy resistance of cancer cells and amplifying the radiotherapeutic efficacy ( GDYCeO 2 nanozyme are synthesized by 2D graphdiyne (GDY) anchoring to the Cerium oxide (CeO 2 ) nanoparticles

Acting as second messengers in the insulin cascade, IPGs facilitate glucose uptake, glycogen synthesis, and lipid metabolism through the activation of key enzymes such as pyruvate dehydrogenase and glycogen synthase (135)