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10.3389/fphar.2018.00530 Front Pharmacol

Sulfate conjugation reactions catalyzed by SOT generate 3-phosphoadenosine 5-phosphate (PAP), a molecule that participates in the organelle-nuclear retrograde signaling, if not dephosphorylated by the SAL1 phosphatase ( FIGURE 1 While many essential steps of the sulfate assimilation and cysteine, methionine and glutathione biosynthesis pathways occur exclusively in plastids, a few enzymes present in the cytosol and mitochondria also come into play, which necessitates a concerted action between enzymes present in different subcellular compartments and intracellular transporters

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