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Neuroprotection could also be observed in response to systemic treatment with 3 mg/kg of foliglurax in mice challenged with MPTP 148

(3) The observed decrease in carnitine and CPT I expression in cardiac tissues by SUN was parallel to the increase in cardiac index, cardiac enzymes and myocardial fibrosis which may point to the possible contribution of carnitine deficiency and the inhibition of CPT I as possible mechanisms in SUN-induced cardiotoxicity

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Trimethylamine and trimethylamine N-Oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease