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It seems that while the negative feedback of the STAT3 signaling delays the insulin/IGF-1-induced aging process, it nonetheless elicits insulin resistance and diabetes

P., Cooper, S

This suggests that the type I IFN response may play a crucial role in supporting a robust immune response against cancer

The TET proteins have been shown to function in transcriptional activation and repression (TET1), tumor suppression (TET2), and DNA methylation reprogramming processes (TET3)