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After 16 years, the patient is still alive and well (Figure 2)

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In advanced stages of chronic hepatitis B (CHB) and HCC, a substantial proportion of HBsAg appears to emanate from integrated DNA rather than from active viral infection [7], and particularly ground glass hepatocytes contain abundant HBsAg [8]

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Here, we focused on one of the proteins recognized with the applied strategy ( Supplementary Figure S1 ): Rv1133c (MetE), which was highly represented in the SCMS and induced a robust humoral immune response in mice, allowing the isolation of several MetE-specific mAbs, suggesting its high immunogenicity

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10.3390/bacteria3010002 232

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