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For testing the difference in mean and median lifespan between groups, we used linear mixed model with linear quantile mixed-effects model, which included cage assignment as a random effect and batch as a covariate, respectively, using package nlme and lgmm in statistical software R

The increase in carbohydrate utilization as an alternative source of ATP production seems to be an earlier event than the decrease in FA oxidation in the progression of cardiac diseases to HF since studies report higher capacities to use glucose as soon as compensated cardiac hypertrophy stage [136,137]

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Many cases of sub-clinical hypothyroidism are transient