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Introduction The nourishment and growth of metastatic tumors require a significant supply of both nutrients and oxygen, which necessitates the development of an autonomous blood supply to the tumor microenvironment (TME) [1-3]

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We began by evaluating known HIV PIs for their efficacies at suppressing precursor autoprocessing and determined performance parameters such as Z-factor, and S/N ratios for assay validation 40,41

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