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Interestingly, in the context of the transgenic mice expressing the mutant human B-crystallin, heterozygous knockout of Nrf2 lessened reductive stress decreasing the expression of the enzymes involved in GSH biosynthesis and recycling, resulting in a decrease in GSH concentration and the GSH/GSSG ratio

Graphical Abstract 1 Introduction The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally identified for its role in mediating the harmful effects of environmental toxins such as dioxin

Pfizer and Amgen both concentrate on lung and thoracic cancers as strategic priorities

gingivalis virulence factors and synergistic interactions within the microbiota may further amplify ferroptotic effects (63)