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Cell Biophys 1983;5:12940

Abnormally high concentrations of Cu have been found in the striatum in patients with HD and in mouse models of HD

TRPV1 (Transient Receptor Potential channels) and TRPA1 ion channels on sensory nerve endings are upregulated, meaning that chemical stimuli that would be imperceptible on healthy skin trigger pain signaling and neurogenic inflammation in rosacea skin