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10.1016/j.dsx.2018.08.035 17

Berberines anti-atherosclerotic efficacy potentially stems from its ability to reduce TMAO production, making it an excellent modulator for inhibiting atherosclerotic plaque development (Chen and Wang, 2021)

Because dialysis patient plasma free levocarnitine level can be starkly lower than normal person's level, the patient of dialysis more than 2 years all the levocarnitine deficiency disease can occur.Levocarnitine lacks can influence the oxidation of mitochondrion to free fatty, causes energy metabolism impairment, simultaneously, and owing to S-acetyl-coenzyme-A gathers at mitochondrion, but the effect of pair cell toxigenicity.Its clinical manifestation is hypotension, muscular spasm, cardiomyopathy, arrhythmia and the reduction of dialysis toleration etc., has a strong impact on patient's quality of life and secular survival rate, so it is very important to replenish levocarnitine

One of the most important compounds for carnitine is Vitamin C, as its synthesis involves different vitamin C-dependent enzymes and its deficiency has a very negative effect on L-carnitine synthesis in the body