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Current experimental systems related to GPX4 research mostly focus on chondrocytes, with clearly insufficient research evidence in synovium, immune cells, and even subchondral bone cells

Metformin, an AMPK-specific agonist, induces autophagy but also induces other signaling pathways, such as the Hedgehog [165] and ROS/JNK [166] signaling pathways, leading to off-target effects

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