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mTOR signaling factors downstream of IGF1R play key roles in the regulation of cancer cell metabolism, lipid and protein synthesis and they are responsible for several metabolic adaptations ( In vitro studies, over-expression of the IGF1R has been identified as a typical hallmark of many types of tumors (Werner et al., 2012)

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Insulin Resistance Insulin resistance means that your body is unable to respond to insulin well and unable to use blood glucose for insulin