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126 Cytochrome c subsequently binds with Apaf-1 and dATP, forming the apoptosome, which recruits and activates initiator caspase-9

Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, Leboeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Snchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Papagiannakopoulos T (2017) Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

observed that aging is associated with lower antioxidant defense capacity (catalase activity and GSH levels), higher levels of oxidative compounds (XO activity/expression, superoxide, ROS, and GSSG levels), and increased lipofuscin accumulation, along with impaired immune cell functions such as macrophages 116

Thus, thorough research on the relationship between organelles and the GPX4-GSH metabolic pathway could yield important insights into the management or avoidance of ferroptosis-related disorders