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Description

Formation of intracellular aggregates of various crystallin proteins was visualized by fluorescence of GFP (green) and the nuclei were stained with Hoechst 33342 (blue)

This delivery method allows the peptide to reach cartilage tissue at therapeutic concentrations while minimizing systemic exposure

In the groups stimulated with 10 ng/mL IGF-I, IRS-1 levels decreased at 6 h, gradually increased again from 18 to 30 h, decreased at 36 h, and increased thrice at 48 h