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JACC Basic Transl Sci

Further in vivo studies showed that in the hearts of MI/R rats, the high-dose PV group (400 mg/kg/d) significantly upregulated the protein level of GPX4, and this upregulatory effect disappeared in Nrf2 knockout mice, indicating that the effect of PV in upregulating the GPX4 protein level is dependent on Nrf2 [182]