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Reduced peri-infarct astrocyte reactivity in C3a-treated mice was associated with upregulation of Igf1 and Thbs4 , coding for insulin-like growth factor 1 (IGF-1) and thrombospondin-4 (THBS4), respectively, both of which are highly expressed in peri-infarct astrocytes 383

Some of its key functions include: Antioxidant Defense : Glutathione neutralizes free radicals and protects cells from oxidative stress, which can lead to cellular damage

In addition, EAAT3 is important for the oxidative balance of neurons since it also transports cysteine, a rate limiting component of glutathione, an important component of baseline oxidative balance in neurons [22]

While short and moderate intermittent hypoxia protocols have shown promising results in preconditioning, repeated exposure over extended periods can become detrimental