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The plasma membrane of neurons is rich in PUFAs and is susceptible to free radical attack and peroxidation of unsaturated carbon-carbon bonds

While GSH has long been recognized as a key brain antioxidant, its role in neurodegenerative diseases is now being unraveled with mechanistic clarity: future research will likely focus on activating astrocytic Nrf2 signaling to enhance glutamate cysteine ligase (GCL)-mediated GSH synthesis, exploring the role of MCT1/2 transporters in neuronal GSH precursor supply, and dissecting how oxidative stress modulates microglial activation via pathways like NF-B-dependent proinflammatory cytokine secretion (Sun et al., 2022)

Nanotoxicology 6(8):847856 Laurencin M, Cam N, Georgelin T, Clment O, Autret G, Siaugue JM, Mnager C (2013) Human erythrocytes covered with magnetic coreshell nanoparticles for multimodal imaging

It is usually progressive