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Importantly, the expression of these genes is controlled by the transcription factor NRF2, and, in fact, the level of this protein was highly reduced in the most sensitive cell line, NCI H23, explaining the reduced expression of genes involved in GSH synthesis (Fig

Monitoring blood drug levels should not affect patient management

The parametric T-test or non-parametric Kruskal-Wallis test was applied for quantitative variables, after checking the normality, using ShapiroWilk or DAgostinoPearson test, and homoscedasticity, using BrownForsythe and Bartletts test