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The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

Interestingly, surviving mature OLGs produce fewer new myelin sheaths than newly formed OLGs, but they better preserve the pattern of myelination in the cortex, with potential implications for functional recovery (Bacmeister et al., What Curbs Spontaneous Myelin Repair

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A large scale high-throughput screening of compounds with remyelinating effects identified a cluster of anti-muscarinic formulations, including clemastine, that enhance OPC differentiation and remyelination in vitro 43