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338 However, in heart failure, DEAD-box helicase 17 and B-cell lymphoma 6 are downregulated, which would reverse the inhibition of Drp1 and promote mitochondrial fission

Research on mixture effects involving multiple EEDs remains an emerging field, with most studies focusing on single-chemical exposures despite the reality of multi-chemical environmental exposure, limiting our understanding of cumulative health risks ( Transgenerational Impacts Lack Adequate Human Documentation Animal studies consistently demonstrate that EED exposure can induce heritable epigenetic modifications affecting offspring fertility across multiple generations

10.1039/c8fo00654g 31 CunhaA