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This leakage further activates microglia towards the M1 phenotype, promoting release of neurotoxic agents, including TNF- and IL-6 (50)

Mutants with a disrupted synthetic pathway contain lower levels of glutathione and are more susceptible to both pathogens and generalist insects 4,14,15,16,17

88,90 Therefore, it is conjectured that high dose N-acetylcysteine can enhance innate and adaptive immunity by elevating stores of glutathione levels in T lymphocytes, along with modulating immune-system responses to alleviate the degree of severity of COVID-19 infection and thus improve patient outcomes

When your stores are depleted, your body struggles to mount an effective defense against infections and recover efficiently from illness